SNP CommunicationGenetic Variations and Haplotypes of UGT1A4 in a Japanese Population
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Cited by (48)
Effects of UGT1A4 genetic polymorphisms on serum lamotrigine concentrations in Chinese children with epilepsy
2015, Drug Metabolism and PharmacokineticsCitation Excerpt :These controversial findings highlight the need to further investigate functional significance of the UGT1A4 142T > G variant in other groups. Other than the SNPs found in exon 1, functional SNPs in the 5’-upstream region of the UGT1A4 gene have also been described [9,13–15]. UGT1A4 expression and glucuronidation activity were reduced in the presence of SNPs at positions −219 and −163 relative to the ATG start codon in exon 1 [14,16].
Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review
2014, Pharmacology and TherapeuticsThe relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy
2011, Epilepsy ResearchCitation Excerpt :The UGT1A4 L48V variant gene frequency was 11.9% for homozygous and 30.9% for heterozygous patients in the LTG exposure group. Another study with a Japanese population has shown 19 distinct genetic variations in the first exon of the UGT1A4 enzyme (Saeki et al., 2005). The UGT1A4 L48V polymorphism was present in 12% of the patients and none of them had P24T polymorphism.
Breast cancer resistance protein polymorphism ABCG2 c.421C>A (rs2231142) moderates the effect of valproate on lamotrigine trough concentrations in adults with epilepsy
2024, Fundamental and Clinical Pharmacology