Double-blind, randomized, placebo controlled pilot study evaluating efficacy and reactogenicity of an oral ETEC B-subunit-inactivated whole cell vaccine against travelers' diarrhea (preliminary report)

G Wiedermann; H Kollaritsch; M Kundi; A M Svennerholm; U Bjare

doi:10.2310/7060.2000.00007

Double-blind, randomized, placebo controlled pilot study evaluating efficacy and reactogenicity of an oral ETEC B-subunit-inactivated whole cell vaccine against travelers' diarrhea (preliminary report)

J Travel Med. 2000 Jan;7(1):27-9. doi: 10.2310/7060.2000.00007.

Authors

G Wiedermann¹, H Kollaritsch, M Kundi, A M Svennerholm, U Bjare

Affiliation

¹ Institute for Specific Prophylaxis and Tropical Medicine, University of Vienna, Austria.

PMID: 10689236
DOI: 10.2310/7060.2000.00007

Abstract

Diarrhea caused by enterotoxigenic E.coli (ETEC) is an important health problem in developing countries and in travelers to these areas. In previous trials formulations of ETEC vaccines containing the B-subunit of cholera toxin, which is antigenically similar to the heat labile enterotoxin of ETEC, and the most prevalent colonization factor antigens of ETEC, were shown to stimulate relevant mucosal immune responses in volunteers from Sweden and Egypt.

Publication types

Clinical Trial
Randomized Controlled Trial

MeSH terms

Adult
Austria
Bacterial Vaccines* / adverse effects
Bacterial Vaccines* / standards
Child
Cholera Toxin / immunology
Cholera Vaccines / adverse effects
Cholera Vaccines / standards
Diarrhea / prevention & control*
Double-Blind Method
Escherichia coli / immunology*
Feces / microbiology
Female
Humans
Male
Pilot Projects
Travel*
Vaccines, Combined
Vaccines, Inactivated
Vibrio cholerae / immunology*

Substances

Bacterial Vaccines
Cholera Vaccines
Vaccines, Combined
Vaccines, Inactivated
Cholera Toxin