Abstract
In a group of 465 patients diagnosed as having chronic mercury toxicity (CMT), 32.3% had severe fatigue, 88.8% had memory loss, and 27.5% had depression. A significant correlation was found between CMT and the Apo-lipoprotein E4 genotype (p=0.001). An investigation into an additional 864 consecutively seen general practice patients, resulted in 30.3% having evidence consistent with CMT, and once again a significant correlation was found with the APO-E4 genotype (p=0.001). Removal of amalgam mercury fillings when combined with appropriate treatment resulted in a significant symptom reduction (p<0.001) to levels reported by healthy subjects.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Apolipoprotein E2 / genetics
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Apolipoprotein E2 / metabolism
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Chronic Disease
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Dental Amalgam / adverse effects
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Dental Restoration, Permanent
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Depression / chemically induced*
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Depression / diagnosis
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Depression / genetics
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Fatigue / chemically induced*
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Fatigue / diagnosis
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Fatigue / genetics
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Female
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Genetic Predisposition to Disease
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Genotype
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Humans
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Male
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Memory Disorders / chemically induced*
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Memory Disorders / diagnosis
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Memory Disorders / genetics
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Mercury / adverse effects
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Mercury / pharmacokinetics
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Mercury Poisoning / diagnosis*
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Mercury Poisoning / genetics
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Mercury Poisoning / therapy*
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Middle Aged
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New Zealand
Substances
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Apolipoprotein E2
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Dental Amalgam
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Mercury