Childhood linear IgA bullous disease triggered by amoxicillin-clavulanic acid

Pediatr Dermatol. 2007 Sep-Oct;24(5):E40-3. doi: 10.1111/j.1525-1470.2007.00438.x.

Abstract

Linear immunoglobulin A bullous disease is an autoimmune subepidermal blistering disease that has been described in both children and adults. Reports have shown that as many as two-thirds of occurrences may be drug-induced. The offending drugs include antibiotics, predominantly vancomycin, nonsteroidal anti-inflammatory agents and diuretics. We report childhood linear immunoglobulin A bullous dermatosis developing following amoxicillin-clavulanic acid administration. The patient presented with characteristic blisters in an annular fashion, likened to a ''crown of jewels.'' The diagnosis was confirmed by the presence of a linear band of immunoglobulin A at the dermoepidermal junction on direct immunofluorescence. The lesions resolved with withdrawal of the drug, and systemic therapy was not required. We review the current literature and concepts of drug-induced linear immunoglobulin A bullous disease.

Publication types

  • Case Reports

MeSH terms

  • Amoxicillin-Potassium Clavulanate Combination / adverse effects*
  • Anti-Bacterial Agents / adverse effects*
  • Child, Preschool
  • Drug Eruptions / immunology
  • Drug Eruptions / pathology*
  • Humans
  • Immunoglobulin A / immunology
  • Male
  • Skin Diseases, Vesiculobullous / chemically induced*
  • Skin Diseases, Vesiculobullous / immunology
  • Skin Diseases, Vesiculobullous / pathology*

Substances

  • Anti-Bacterial Agents
  • Immunoglobulin A
  • Amoxicillin-Potassium Clavulanate Combination