Anticoagulation therapy is essential in the prevention of thromboembolic events in a variety of patient groups, but has a high risk/benefit profile. Patient adherence and careful control of therapeutic levels of medication require frequent monitoring and good communication. An emerging model of care is nurse-managed anticoagulation clinics, which provide a focused and organized approach. This institution found that registered nurses were successful in providing consistent patient education and relationship-based care, which appear to improve compliance and minimize complications. The patient group that received the care of the nurse-managed anticoagulation clinic had outcomes that were better than those of patients managed by the previous model. More randomized controlled studies are needed to validate and enhance improved patient outcomes.