Abstract
Acanthosis nigricans is a dermatosis characterized by thickened, hyperpigmented plaques, typically of the intertriginous surfaces and neck. Common in some populations, its prevalence depends on race. Clinicians should recognize acanthosis nigricans; it heralds disorders ranging from endocrinologic disturbances to malignancy. In this review, we discuss the pathogenesis of acanthosis nigricans and its clinical implications and management.
MeSH terms
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Acanthosis Nigricans* / diagnosis
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Acanthosis Nigricans* / drug therapy
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Acanthosis Nigricans* / epidemiology
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Acanthosis Nigricans* / etiology
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Acanthosis Nigricans* / pathology
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Acanthosis Nigricans* / radiotherapy
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Adolescent
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Calcitriol / analogs & derivatives
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Calcitriol / pharmacology
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Child
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Disease Susceptibility
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Ethnicity / genetics
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Female
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Fish Oils / therapeutic use
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Humans
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Hypoglycemic Agents / therapeutic use
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Insulin Resistance
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Insulin-Like Growth Factor I / physiology
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Low-Level Light Therapy
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Male
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Neoplasms / complications
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Prevalence
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Receptor Protein-Tyrosine Kinases / physiology
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Retinoids / therapeutic use
Substances
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Fish Oils
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Hypoglycemic Agents
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Retinoids
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calcipotriene
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Insulin-Like Growth Factor I
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Receptor Protein-Tyrosine Kinases
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Calcitriol