Abstract
To determine the effectiveness of an antiviral to prevent herpes labialis during a brief, high-risk circumstance, 147 persons with a history of sun-induced recurrences were treated prophylactically with oral acyclovir or matching placebo and were observed during their ski holidays. Five (7%) of 75 acyclovir-treated subjects developed lesions compared with 19 (26%) of 72 persons in the placebo group.
Publication types
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Clinical Trial
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclovir / therapeutic use*
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Administration, Oral
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Adult
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Colorado
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Drug Administration Schedule
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Female
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Herpes Labialis / prevention & control*
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Humans
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Male
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Random Allocation
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Recurrence
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Risk Factors
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Skiing*
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Sunlight / adverse effects
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Sunscreening Agents / therapeutic use
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Utah
Substances
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Sunscreening Agents
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Acyclovir