Given the high attrition rates, substantial costs and slow pace of new drug discovery and
development, repurposing of'old'drugs to treat both common and rare diseases is increasingly …

Alzheimer’s disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

An important, but often neglected, contribution to the thermodynamics of protein folding is the
loss of entropy that results from restricting the number of accessible side‐chain conformers …

… We became quite skilful at doing vector operations by … applying a French pronunciation to
‘Land-Doig’, so we don’t think … ), which in fact was what we were doing by not leaving a node of …

The ability to predict protein function from structure is becoming increasingly important as
the number of structures resolved is growing more rapidly than our capacity to study function. …

Most analyses of organic blood components are presently performed by spectrophotometric
methods. Recently, many of these methods have utilized enzyme catalyzed reactions …

We have determined the N‐ and C‐capping preferences of all 20 amino acids by
substituting residue X in the peptides NH 2 ‐XAKAAAAKAAAAKAAGY‐CONH 2 and in Ac‐…

I ntegrated Waste Management is one of the holistic approaches to environmental and resource
management which are emerging from applying the concept of sustainable development…

Motivation: We analysed 148 human drug target proteins and 3573 non-drug targets to
identify differences in their properties and to predict new potential drug targets. Results: Drug …

Highlights • We review recent drugs mainly targeting Aβ and how they were identified. • We
report their results from in vitro and in vivo experiments and clinical trials. • We describe …