[HTML][HTML] Reconstruction of the personal information from human genome reads in gut metagenome sequencing data

…, T Kurakawa, M Yagita-Sakamaki, A Hosokawa… - Nature …, 2023 - nature.com
Human DNA present in faecal samples can result in a small number of human reads in gut
shotgun metagenomic sequencing data. However, it is presently unclear how much personal …

Prenatal exposure to HMG-CoA reductase inhibitors: effects on fetal and neonatal outcomes

N Taguchi, ET Rubin, A Hosokawa, J Choi… - Reproductive …, 2008 - Elsevier
BACKGROUND: Use of HMG-CoA reductase inhibitors (statins) is becoming increasingly
common. However, a recent study based on a series of cases reported to FDA suggests …

Whole gut virome analysis of 476 Japanese revealed a link between phage and autoimmune disease

…, K Sonehara, M Yagita, A Hosokawa… - Annals of the …, 2022 - ard.bmj.com
Objective The relationship between autoimmune diseases and the gut microbiome has
been intensively studied, and several autoimmunity-associated bacterial taxa have been …

[HTML][HTML] A metagenome-wide association study of gut microbiome in patients with multiple sclerosis revealed novel disease pathology

…, K Ogawa, D Motooka, A Hosokawa… - Frontiers in cellular …, 2020 - frontiersin.org
While microbiome plays key roles in the etiology of multiple sclerosis (MS), its mechanism
remains elusive. Here, we conducted a comprehensive metagenome-wide association study (…

[PDF][PDF] Prokaryotic and viral genomes recovered from 787 Japanese gut metagenomes revealed microbial features linked to diets, populations, and diseases

…, K Yamamoto, K Sonehara, M Yagita, A Hosokawa… - Cell Genomics, 2022 - cell.com
We reconstructed 19,084 prokaryotic and 31,395 viral genomes from 787 Japanese gut
metagenomes as Japanese metagenome-assembled genomes (JMAG) and Japanese Virus …

Comparative effects of cyclo‐oxygenase and nitric oxide synthase inhibition on the development and reversal of spinal opioid tolerance

KJ Powell, A Hosokawa, A Bell, M Sutak… - British journal of …, 1999 - Wiley Online Library
This study examined the effects of the COX inhibitors, ketorolac and ibuprofen, and the NOS
inhibitor L‐NAME for their potential to both inhibit the development and reverse tolerance to …

[HTML][HTML] Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese

K Ogawa, T Okuno, K Hosomichi, A Hosokawa… - Journal of …, 2019 - Springer
Background The spectrum of classical and non-classical HLA genes related to the risk of
multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) in the Japanese …

Use of lipid-lowering agents (statins) during pregnancy.

A Hosokawa, B Bar-Oz, S Ito - Canadian Family Physician, 2003 - cfp.ca
QUESTION: A 34-year-old patient of mine is taking a 'statin' for hyperlipidemia. She is
planning pregnancy and is worried about the safety of the drug. How should I advise her? …

[PDF][PDF] Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population

…, N Arase, M Yagita-Sakamaki, A Hosokawa… - Cell Reports, 2023 - cell.com
Interaction between the gut microbiome and host plays a key role in human health. Here,
we perform a metagenome shotgun-sequencing-based analysis of Japanese participants to …

A novel mutation of the KAL1 gene in monozygotic twins with Kallmann syndrome

…, S Okamoto, Y Izumi, A Hosokawa… - European journal of …, 2000 - academic.oup.com
Objective Kallmann syndrome is defined by the association of hypogonadotropic hypogonadism
and anosmia. The KAL1 gene is responsible for the X-linked form of Kallmann syndrome…