The comet assay is a versatile and sensitive method for measuring single- and double-strand
breaks in DNA. The mechanism of formation of comets (under neutral or alkaline conditions…

The endogenous production of oxidative damage in DNA by free radicals released as a by-product
of respiration is a likely cause of mutations which, if they occur in appropriate genes, …

The association between high intake of fruit and vegetables and low incidence of certain
cancers is well established. Dietary antioxidants present in these foods are thought to decrease …

This second volume of Chirality in Industry contains new case histories from a wide range of
contributors from industry or with strong industrial connections. While it is intended that the …

The comet assay (single-cell gel electrophoresis) is a simple method for measuring
deoxyribonucleic acid (DNA) strand breaks in eukaryotic cells. Cells embedded in agarose on a …

Abstract Analysis of single nucleotide polymorphisms (SNPs) has been and will be increasingly
utilized in various genetic disciplines, particularly in studying genetic determinants of …

A range of applications of the alkaline comet assay is covered, from investigations of the
physicochemical behaviour of DNA, through studies of cellular responses to DNA damage, to …

Single cell gel electrophoresis is a sensitive method for detecting DNA strand breaks. Cells
embedded in agarose are converted to nucleoids by treating with detergent and high salt. …

Oxidized bases in DNA can be measured directly by high-performance liquid chromatography
(HPLC). 7,8-Dihydro-8-oxo-guanine (8-OHgua), as the most abundant oxidation product, …

The comet assay (single‐cell gel electrophoresis), which measures DNA strand breaks at the
level of single cells, is very easily applied to human lymphocytes, and therefore lends itself …