Photodynamic therapy (PDT) is an emerging treatment modality for a range of disease classes,
both cancerous and noncancerous. This has brought about an active pursuit of new PDT …

INTRODUCTION In human cells, 2 m of DNA are compacted in the nucleus through assembly
with histones and other proteins into chromatin structures, megabase three-dimensional (…

The 4D Nucleome Network aims to develop and apply approaches to map the structure and
dynamics of the human and mouse genomes in space and time with the goal of gaining …

Background The gut is the most extensively studied niche of the human microbiome. The
aim of this study was to characterise the initial gut microbiota development of a cohort of …

ONYX-015 is an adenovirus that lacks the E1B-55K gene product for p53 degradation. Thus,
ONYX-015 was conceived as an oncolytic virus that would selectively replicate in p53-…

The intradermal (ID) space has been actively explored as a means for drug delivery and
diagnostics that is minimally invasive. Microneedles or microneedle patches or microarray …

… using the following PCR program: 95 C for 2 min; 30 cycles of 94 C for 1 min, 52 C for 1 min,
72 C for 2 min; 72 C of 15 min; and holding at 4 C. Chimaeric constructs that contained the …

Human milk contains a diverse array of bioactives and is also a source of bacteria for the
developing infant gut. The aim of this study was to characterize the bacterial communities in …

Transcription factors (TFs) are master regulators of abiotic stress responses in plants. This
review focuses on TFs from seven major TF families, known to play functional roles in …

There is currently much interest in the idea of restoring p53 activity in tumor cells by inhibiting
Hdm2/Mdm2. However, it has remained unclear whether this would also activate p53 in …