User profiles for Christine Brown

Christine Brown

City of Hope
Verified email at coh.org
Cited by 14571

[HTML][HTML] Regression of glioblastoma after chimeric antigen receptor T-cell therapy

CE Brown, D Alizadeh, R Starr, L Weng… - … England Journal of …, 2016 - Mass Medical Soc
<p id="p001">A patient with recurrent multifocal glioblastoma received chimeric antigen
receptor (CAR)–engineered T cells targeting the tumor-associated antigen interleukin-13 …

CAR T cells for brain tumors: Lessons learned and road ahead

…, MR Weist, JK Shepphird, CE Brown - Immunological …, 2019 - Wiley Online Library
Malignant brain tumors, including glioblastoma, represent some of the most difficult to treat
of solid tumors. Nevertheless, recent progress in immunotherapy, across a broad range of …

Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer

…, S Wright, S Pal, RE Reiter, AM Wu, CE Brown… - …, 2018 - Taylor & Francis
Advancing chimeric antigen receptor (CAR)-engineered adoptive T cells for the treatment of
solid cancers is a major focus in the field of immunotherapy, given impressive recent clinical …

Bioactivity and Safety of IL13Rα2-Redirected Chimeric Antigen Receptor CD8+ T Cells in Patients with Recurrent Glioblastoma

CE Brown, B Badie, ME Barish, L Weng, JR Ostberg… - Clinical cancer …, 2015 - AACR
Purpose: A first-in-human pilot safety and feasibility trial evaluating chimeric antigen
receptor (CAR)–engineered, autologous primary human CD8 + cytotoxic T lymphocytes (CTL) …

The many HATs of transcription coactivators

CE Brown, T Lechner, LA Howe, JL Workman - Trends in biochemical …, 2000 - cell.com
Histone acetylation is closely linked to gene transcription. The identification of histone
acetyltransferases (HATs) and the large multiprotein complexes in which they reside has yielded …

The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study

…, C Hegadorn, J Leggo, A Tuttle, S Tinlin, C Brown… - Blood, 2007 - ashpublications.org
In order to evaluate the changes within the VWF gene that might contribute to the pathogenesis
of type 1 von Willebrand disease (VWD), a large multicenter Canadian study was …

Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit

CE Brown, LA Howe, K Sousa, SC Alley, MJ Carrozza… - Science, 2001 - science.org
Promoter-specific recruitment of histone acetyltransferase activity is often critical for
transcriptional activation. We present a detailed study of the interaction between the histone …

T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia

…, C Dos Santos, T McDonald, CE Brown… - Blood, The Journal …, 2013 - ashpublications.org
Induction treatments for acute myeloid leukemia (AML) have remained largely unchanged
for nearly 50 years, and AML remains a disease of poor prognosis. Allogeneic hematopoietic …

Establishing the critical elements that determine authentic assessment

…, J Herrington, C Brown - Assessment & Evaluation …, 2014 - Taylor & Francis
This study sought to determine the critical elements of an authentic learning activity, design
them into an applicable framework and then use this framework to guide the design, …

Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells

KS Kahlon, C Brown, LJN Cooper, A Raubitschek… - Cancer research, 2004 - AACR
The interleukin (IL) 13 receptor α2 (IL13Rα2) is a glioma-restricted cell-surface epitope not
otherwise detected within the central nervous system. Here, we describe a novel approach for …