User profiles for Christine Brown
Christine BrownCity of Hope Verified email at coh.org Cited by 14571 |
[HTML][HTML] Regression of glioblastoma after chimeric antigen receptor T-cell therapy
CE Brown, D Alizadeh, R Starr, L Weng… - … England Journal of …, 2016 - Mass Medical Soc
<p id="p001">A patient with recurrent multifocal glioblastoma received chimeric antigen
receptor (CAR)–engineered T cells targeting the tumor-associated antigen interleukin-13 …
receptor (CAR)–engineered T cells targeting the tumor-associated antigen interleukin-13 …
CAR T cells for brain tumors: Lessons learned and road ahead
…, MR Weist, JK Shepphird, CE Brown - Immunological …, 2019 - Wiley Online Library
Malignant brain tumors, including glioblastoma, represent some of the most difficult to treat
of solid tumors. Nevertheless, recent progress in immunotherapy, across a broad range of …
of solid tumors. Nevertheless, recent progress in immunotherapy, across a broad range of …
Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer
Advancing chimeric antigen receptor (CAR)-engineered adoptive T cells for the treatment of
solid cancers is a major focus in the field of immunotherapy, given impressive recent clinical …
solid cancers is a major focus in the field of immunotherapy, given impressive recent clinical …
Bioactivity and Safety of IL13Rα2-Redirected Chimeric Antigen Receptor CD8+ T Cells in Patients with Recurrent Glioblastoma
Purpose: A first-in-human pilot safety and feasibility trial evaluating chimeric antigen
receptor (CAR)–engineered, autologous primary human CD8 + cytotoxic T lymphocytes (CTL) …
receptor (CAR)–engineered, autologous primary human CD8 + cytotoxic T lymphocytes (CTL) …
The many HATs of transcription coactivators
Histone acetylation is closely linked to gene transcription. The identification of histone
acetyltransferases (HATs) and the large multiprotein complexes in which they reside has yielded …
acetyltransferases (HATs) and the large multiprotein complexes in which they reside has yielded …
The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study
…, C Hegadorn, J Leggo, A Tuttle, S Tinlin, C Brown… - Blood, 2007 - ashpublications.org
In order to evaluate the changes within the VWF gene that might contribute to the pathogenesis
of type 1 von Willebrand disease (VWD), a large multicenter Canadian study was …
of type 1 von Willebrand disease (VWD), a large multicenter Canadian study was …
Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit
Promoter-specific recruitment of histone acetyltransferase activity is often critical for
transcriptional activation. We present a detailed study of the interaction between the histone …
transcriptional activation. We present a detailed study of the interaction between the histone …
T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia
…, C Dos Santos, T McDonald, CE Brown… - Blood, The Journal …, 2013 - ashpublications.org
Induction treatments for acute myeloid leukemia (AML) have remained largely unchanged
for nearly 50 years, and AML remains a disease of poor prognosis. Allogeneic hematopoietic …
for nearly 50 years, and AML remains a disease of poor prognosis. Allogeneic hematopoietic …
Establishing the critical elements that determine authentic assessment
…, J Herrington, C Brown - Assessment & Evaluation …, 2014 - Taylor & Francis
This study sought to determine the critical elements of an authentic learning activity, design
them into an applicable framework and then use this framework to guide the design, …
them into an applicable framework and then use this framework to guide the design, …
Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells
KS Kahlon, C Brown, LJN Cooper, A Raubitschek… - Cancer research, 2004 - AACR
The interleukin (IL) 13 receptor α2 (IL13Rα2) is a glioma-restricted cell-surface epitope not
otherwise detected within the central nervous system. Here, we describe a novel approach for …
otherwise detected within the central nervous system. Here, we describe a novel approach for …