User profiles for Christopher H. Mody

Mody Christopher H

Microbiology Immunology and Infectious Disease, University of Calgary
Verified email at ucalgary.ca
Cited by 6093

An official American Thoracic Society statement: treatment of fungal infections in adult pulmonary and critical care patients

…, CA Hage, KA Marr, CH Mody… - American journal of …, 2011 - atsjournals.org
With increasing numbers of immune-compromised patients with malignancy, hematologic
disease, and HIV, as well as those receiving immunosupressive drug regimens for the …

[HTML][HTML] Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain

…, KS Kim, H Zhou, P Kubes, CH Mody - The Journal of …, 2010 - Am Soc Clin Investig
Infectious meningitis and encephalitis is caused by invasion of circulating pathogens into
the brain. It is unknown how the circulating pathogens dynamically interact with brain …

Cryptococcus

SS Li, CH Mody - Proceedings of the American Thoracic Society, 2010 - atsjournals.org
Cryptococcus is a unique environmental fungus. Among the more than three dozen species
of Cryptococcus, only C. neoformans and C. gattii commonly cause disease. Although many …

Primary Dendritic Cells Phagocytose Cryptococcus neoformans via Mannose Receptors and Fcγ Receptor II for Presentation to T Lymphocytes

…, EK Amankwah, FHY Green, CH Mody - Infection and …, 2002 - Am Soc Microbiol
Different “professional” antigen-presenting cells (APC) have unique characteristics that
favor or restrict presentation of microbial antigens to T cells, depending on the organism. …

CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15

…, S Epelman, AM Krensky, CH Mody - The Journal of …, 2002 - journals.aai.org
Granulysin is located in the acidic granules of cytotoxic T cells. Although the purified protein
has antimicrobial activity against a broad spectrum of microbial pathogens, direct evidence …

A Mutation in the mip Gene Results in an Attenuation of Legionella pneumophila Virulence

NP Cianciotto, BI Eisenstein, CH Mody… - Journal of Infectious …, 1990 - academic.oup.com
Infection by Legionella pneumophila is believed to depend upon its ability to multiply within
host alveolar macrophages. To investigate this, a site-specific mutation was introduced into a …

NK cells use perforin rather than granulysin for anticryptococcal activity

…, S Epelman, AM Krensky, CH Mody - The Journal of …, 2004 - journals.aai.org
Cytotoxic lymphocytes have the capacity to kill microbes directly; however, the mechanisms
involved are poorly understood. Using Cryptococcus neoformans, which causes a potentially …

[PDF][PDF] The NK receptor NKp30 mediates direct fungal recognition and killing and is diminished in NK cells from HIV-infected patients

…, SM Huston, A Islam, MJ Gill, SM Robbins, CH Mody - Cell host & …, 2013 - cell.com
Natural killer (NK) cells are a subset of immune effectors that directly bind and kill fungi via a
perforin-dependent mechanism. The receptor mediating this activity and its potential role in …

Herpes simplex virus 1 UL24 abrogates the DNA sensing signal pathway by inhibiting NF-κB activation

H Xu, C Su, A Pearson, CH Mody, C Zheng - Journal of virology, 2017 - Am Soc Microbiol
Cyclic GMP-AMP synthase (cGAS) is a newly identified DNA sensor that recognizes foreign
DNA, including the genome of herpes simplex virus 1 (HSV-1). Upon binding of viral DNA, …

Depletion of CD4+ (L3T4+) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans.

CH Mody, MF Lipscomb, NE Street… - Journal of immunology …, 1990 - journals.aai.org
T cell-mediated immunity has been shown to play an important role in the host defense to
Cryptococcus neoformans. Infections due to C. neoformans are increased in patients with …