User profiles for Christopher H. Mody
Mody Christopher HMicrobiology Immunology and Infectious Disease, University of Calgary Verified email at ucalgary.ca Cited by 6093 |
An official American Thoracic Society statement: treatment of fungal infections in adult pulmonary and critical care patients
…, CA Hage, KA Marr, CH Mody… - American journal of …, 2011 - atsjournals.org
With increasing numbers of immune-compromised patients with malignancy, hematologic
disease, and HIV, as well as those receiving immunosupressive drug regimens for the …
disease, and HIV, as well as those receiving immunosupressive drug regimens for the …
[HTML][HTML] Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain
Infectious meningitis and encephalitis is caused by invasion of circulating pathogens into
the brain. It is unknown how the circulating pathogens dynamically interact with brain …
the brain. It is unknown how the circulating pathogens dynamically interact with brain …
Cryptococcus
Cryptococcus is a unique environmental fungus. Among the more than three dozen species
of Cryptococcus, only C. neoformans and C. gattii commonly cause disease. Although many …
of Cryptococcus, only C. neoformans and C. gattii commonly cause disease. Although many …
Primary Dendritic Cells Phagocytose Cryptococcus neoformans via Mannose Receptors and Fcγ Receptor II for Presentation to T Lymphocytes
…, EK Amankwah, FHY Green, CH Mody - Infection and …, 2002 - Am Soc Microbiol
Different “professional” antigen-presenting cells (APC) have unique characteristics that
favor or restrict presentation of microbial antigens to T cells, depending on the organism. …
favor or restrict presentation of microbial antigens to T cells, depending on the organism. …
CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15
…, S Epelman, AM Krensky, CH Mody - The Journal of …, 2002 - journals.aai.org
Granulysin is located in the acidic granules of cytotoxic T cells. Although the purified protein
has antimicrobial activity against a broad spectrum of microbial pathogens, direct evidence …
has antimicrobial activity against a broad spectrum of microbial pathogens, direct evidence …
A Mutation in the mip Gene Results in an Attenuation of Legionella pneumophila Virulence
NP Cianciotto, BI Eisenstein, CH Mody… - Journal of Infectious …, 1990 - academic.oup.com
Infection by Legionella pneumophila is believed to depend upon its ability to multiply within
host alveolar macrophages. To investigate this, a site-specific mutation was introduced into a …
host alveolar macrophages. To investigate this, a site-specific mutation was introduced into a …
NK cells use perforin rather than granulysin for anticryptococcal activity
…, S Epelman, AM Krensky, CH Mody - The Journal of …, 2004 - journals.aai.org
Cytotoxic lymphocytes have the capacity to kill microbes directly; however, the mechanisms
involved are poorly understood. Using Cryptococcus neoformans, which causes a potentially …
involved are poorly understood. Using Cryptococcus neoformans, which causes a potentially …
[PDF][PDF] The NK receptor NKp30 mediates direct fungal recognition and killing and is diminished in NK cells from HIV-infected patients
Natural killer (NK) cells are a subset of immune effectors that directly bind and kill fungi via a
perforin-dependent mechanism. The receptor mediating this activity and its potential role in …
perforin-dependent mechanism. The receptor mediating this activity and its potential role in …
Herpes simplex virus 1 UL24 abrogates the DNA sensing signal pathway by inhibiting NF-κB activation
Cyclic GMP-AMP synthase (cGAS) is a newly identified DNA sensor that recognizes foreign
DNA, including the genome of herpes simplex virus 1 (HSV-1). Upon binding of viral DNA, …
DNA, including the genome of herpes simplex virus 1 (HSV-1). Upon binding of viral DNA, …
Depletion of CD4+ (L3T4+) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans.
CH Mody, MF Lipscomb, NE Street… - Journal of immunology …, 1990 - journals.aai.org
T cell-mediated immunity has been shown to play an important role in the host defense to
Cryptococcus neoformans. Infections due to C. neoformans are increased in patients with …
Cryptococcus neoformans. Infections due to C. neoformans are increased in patients with …