Matrix metalloproteinase-14 (MMP-14) is a clinically relevant target in metastatic cancers
due to its role in tumor progression and metastasis. Since active MMP-14 is localized on the …

Adjuvants play attractive roles in enhancement of immune response during vaccination;
however, due to several challenges, only a limited number of adjuvants are licensed by health …

Epithelial ovarian cancer (EOC) is a leading cause of cancer-related death in women. EOC
is often diagnosed at late stages, with peritoneal metastases and ascites production. Current …

Chemokine receptors typically have multiple ligands. Consequently, treatment with a blocking
antibody against a single chemokine is expected to be insufficient for efficacy. Here we …

MicroRNA-206 (miR-206) has demonstrated tumor suppressive effects in a variety of cancers.
Numerous studies have identified aberrantly expressed targets of miR-206 that contribute …

Background Failure of immunotherapy in high-grade serous ovarian cancer (HGSC) may be
due to high levels of transforming growth factor-β (TGF-β) in ascites or tumour immune …

Introduction: Hearing loss (HL) is considered a potentially modifiable risk factor for dementia.
We aimed to examine the relationship between HL and incident dementia diagnosis in a …

Amplification of HER2 leads to development of HER2-positive (HER2+) cancers with high
rates of metastasis compared to other cancer subtypes. The goal of this study was to probe the …

Metastatic renal cell carcinoma (mRCC) is a devastating disease with a 5-year survival rate
of approximately 9 % and low response to chemotherapy and radiotherapy. Targeted …

Objective To provide family physicians with a practical evidence-based approach to the
management of patients with hearing loss. Sources of information MEDLINE and PubMed …