SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune
protection against COVID-19. Here, we systematically mapped the functional and phenotypic …

HIV infection is associated with the progressive loss of CD4 + T cells through their destruction
or decreased production 1 , 2 . A central, yet unresolved issue of HIV disease is the …

Chronic activation of the immune system is a hallmark of progressive HIV infection and better
predicts disease outcome than plasma viral load, yet its etiology remains obscure. Here we …

The methodology for EPOS2012 has been the same as for the other two productions. Leaders
in the field were invited to critically appraise the literature and write a report on a subject …

The suite of currently used drugs can be divided into two categories – traditional ‘small
molecule’ drugs with typical molecular weights of <500 Da but with oral bioavailability, and much …

Background Concerns regarding potential neurological complications of COVID-19 are being
increasingly reported, primarily in small series. Larger studies have been limited by both …

The mechanisms underlying CD4 + T cell depletion in human immunodeficiency virus (HIV)
infection are not well understood. Comparative studies of lymphoid tissues, where the vast …

Immunological memory is thought to depend on a stem cell–like, self-renewing population
of lymphocytes capable of differentiating into effector cells in response to antigen re-exposure. …

Flow cytometric detection of antigen-specific CD8+ T cells has previously been limited to
MHC-class I tetramer staining or intracellular cytokine production, neither of which measure the …

Background Allergic rhinitis (AR) affects 10% to 40% of the population. It reduces quality of
life and school and work performance and is a frequent reason for office visits in general …