Thirty‐nine tumor‐bearing patients with metastatic melanoma were treated with 3 subcutaneous
injections of the MAGE‐3.A1 peptide at monthly intervals. No significant toxicity was …

Background We conducted a randomized trial of prophylactic cranial irradiation in patients
with extensive small-cell lung cancer who had had a response to chemotherapy. Methods …

PURPOSE The aim of this trial was to compare the activity and toxicity of single-agent
doxorubicin with that of two multidrug regimens in the treatment of patients with adult advanced …

Purpose Temozolomide is a well-tolerated oral alkylating agent with activity in the CNS. A
multicenter, open-label, phase II study was conducted to assess the safety and efficacy of …

Purpose Prophylactic cranial irradiation (PCI) in patients with extensive-disease small-cell
lung cancer (ED-SCLC) leads to significantly fewer symptomatic brain metastases and …

Purpose : Cervical cancer, the second most common malignancy in women worldwide, is
almost invariably associated with infection by human papillomavirus (HPV). HPV-16 or -18 is …

Clinical nurse education is a major part of all undergraduate programs preparing nurses for
competent professional practice. While research mostly evaluated specific clinical education …

Purpose Cigarette smoking induces CYP1A1/1A2 and is hypothesized to alter erlotinib
pharmacokinetics. This study aimed to determine the maximum tolerated dose (MTD) of erlotinib …

Purpose To determine the feasibility, toxicity, and immunologic effects of vaccination with
autologous tumor cells retrovirally transduced with the GM-CSF gene, we performed a …

A mathematical model incorporating descriptions of tumour growth kinetics and the effects
of cytotoxic chemotherapy on established tumours, is presented. It is shown how models of …