Chronic inflammation characterized by T cell and macrophage infiltration of visceral adipose
tissue (VAT) is a hallmark of obesity-associated insulin resistance and glucose intolerance. …

Obesity and its associated metabolic syndromes represent a growing global challenge, yet
mechanistic understanding of this pathology and current therapeutics are unsatisfactory. We …

Obesity is associated with numerous inflammatory conditions including atherosclerosis,
autoimmune disease and cancer. Although the precise mechanisms are unknown, obesity‐…

Type 1 diabetes (T1D) is caused by autoimmune β cell destruction. The early events triggering
T1D and the forces that keep diabetic autoimmunity pancreas specific have been unclear. …

… (B) Surprisingly, glucose tolerance is impaired in sP equation image mice compared to
wild-type C57BL/6 controls following intraperitoneal injection of 1 g/kg glucose solution (p < 0.01, …

… G: Purified pSC cultures show astrocyte-like dendritic morphology (400×; GFAP, green). H:
IFN-γ–treated pSC cultures do not express MHC class II (red). GFAP (green); nuclear DAPI …

… G: Biacore analysis of transgenic (left panel) vs. endogenous B7–H1 wild type (right panel)
… G: Biacore analysis of transgenic (left panel) vs. endogenous B7–H1 wild type (right panel) …

Multiple sclerosis (MS) is a chronic progressive, demyelinating condition whose therapeutic
needs are unmet, and whose pathoetiology is elusive. We report that transient receptor …

Interleukin-15 (IL-15) is a cytokine important for the development, maturation, and function
of many cells of the immune system including NK, NKT, γδT, and CD8 + T cells. The …

… 2G). 2CA effects included decreased total cell numbers and CD4 + and CD8 + T cell
percentages in lung-draining lymph nodes, accompanied by a slight increase in B-cell proportions (…