Quorum sensing relies upon the interaction of a diffusible signal molecule with a transcriptional
activator protein to couple gene expression with cell population density. In Gram-…

The ultimate objective of biomedical research is to connect human diseases with the genes
that underlie them and drugs that treat them. But this remains a daunting task, and even the …

Na + , K + -ATPase is ubiquitously expressed in the plasma membrane ofall animal cells
where it serves as the principal regulator of intracellularion homeostasis. Na + , K + -ATPase is …

To pursue a systematic approach to the discovery of functional connections among diseases,
genetic perturbation, and drug action, we have created the first installment of a reference …

Recent work has revealed the existence of a class of small non-coding RNA species, known
as microRNAs (miRNAs), which have critical functions across various biological processes …

We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and
disease states are connected by virtue of common gene-expression signatures. Here, we …

The autism spectrum disorders (ASDs) are a group of conditions characterized by impairments
in reciprocal social interaction and communication, and the presence of restricted and …

… in 1963 with Professor Donald J. Cram on electrophilic substitution at saturated carbon.
He received an NSF postdoctoral fellowship for the 1962-1963 academic year to work with …

The genetics of complex disease produce alterations in the molecular interactions of cellular
pathways whose collective effect may become clear through the organized structure of …

Treating messenger RNA transcript abundances as quantitative traits and mapping gene
expression quantitative trait loci for these traits has been pursued in gene-specific ways. …