User profiles for James McCormack

James McCormack

Professor UBC university of British Columbia
Verified email at interchange.ubc.ca
Cited by 3624

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

JG McCormack, AP Halestrap… - Physiological …, 1990 - journals.physiology.org
The role of changes in cytosolic concentrations of Ca2+(here, Ca2+ refers exclusively to free
calcium ions) in the regulation of key cellular systems, such as muscle contraction, secretion…

Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions: potential for pharmacological interventions

…, GD Lopaschuk, JL Hall, JG McCormack - Cardiovascular …, 1997 - academic.oup.com
The regulation of mammalian myocardial carbohydrate metabolism is complex in that it is
linked to arterial substrate and hormone levels, coronary flow, inotropic state and the nutritional …

Regulation of energy substrate metabolism in the diabetic heart

…, GD Lopaschuk, JG McCormack - Cardiovascular …, 1997 - academic.oup.com
Following a myocardial infarction diabetic patients have almost twice the rate of mortality
and 3 times the rate of progression to congestive heart failure when compared to wx …

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

JG McCORMACK, RM Denton - Biochemical Journal, 1979 - portlandpress.com
1. The effects of Ca2+ (mainly by using EGTA buffers), pH, ATP and ADP on the activity of
the 2-oxoglutarate dehydrogenase complex from pig heart were explored. 2. Ca2+ (about 30 …

[PDF][PDF] On the role of the calcium transport cycle in heart and other mammalian mitochondria

RM Denton, JG McCormack - FEBS letters, 1980 - core.ac.uk
Much attention has been focussed recently on the transfer of Ca*+ across the inner membrane
of mammalian mitochondria and within the last year or so this Journal has published two …

Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts

JG McCormack, RL Barr, AA Wolff, GD Lopaschuk - Circulation, 1996 - Am Heart Assoc
Background Ranolazine is a novel antianginal agent that may reduce symptoms without
affecting hemodynamics and has shown cardiac antiischemic effects in in vivo and in vitro …

Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate …

RM Denton, JG Mccormack, NJ Edgell - Biochemical Journal, 1980 - portlandpress.com
1. In uncoupled rat heart mitochondria, the kinetic parameters for oxoglutarate oxidation
were very close to those found for oxoglutarate dehydrogenase activity in extracts of the …

[HTML][HTML] Proteome analysis reveals phosphorylation of ATP synthase β-subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes

…, A Handberg, F Dela, J Vinten, JG McCormack… - Journal of Biological …, 2003 - ASBMB
Insulin resistance in skeletal muscle is a hallmark feature of type 2 diabetes. An increasing
number of enzymes and metabolic pathways have been implicated in the development of …

What patients want to know about their medications. Focus group study of patient and clinician perspectives.

K Nair, L Dolovich, A Cassels, J McCormack… - Canadian Family …, 2002 - cfp.ca
OBJECTIVE To describe what patients want to know about their medications and how they
currently access information. To describe how physicians and pharmacists respond to patients…

Drugs in the news: an analysis of Canadian newspaper coverage of new prescription drugs

…, C Cole, B Mintzes, J Lexchin, JP McCormack - Cmaj, 2003 - Can Med Assoc
Background: Patients routinely cite the media, after physicians and pharmacists, as a key
source of information on new drugs, but there has been little research on the quality of drug …