Insulin receptors are widely distributed in the central nervous system of the rat

J Havrankova, J Roth, M BROWNSTEIN - Nature, 1978 - nature.com
WHILE insulin can affect the function of the central nervous system (CNS) by producing
hypoglycaemia, there is substantial evidence suggesting that insulin can also act directly on cells …

Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state

…, H Beauregard, JM Ékoé, H Fournier, J Havrankova - Cmaj, 2003 - Can Med Assoc
DIABETIC KETOACIDOSIS AND THE HYPERGLYCEMIC hyperosmolar state are the most
serious complications of diabetic decompensation and remain associated with excess …

Concentrations of insulin and of insulin receptors in the brain are independent of peripheral insulin levels: studies of obese and streptozotocin-treated rodents

J Havrankova, J Roth - The Journal of clinical investigation, 1979 - Am Soc Clin Investig
In view of the potent influences of the central nervous system on glucose metabolism and on
its hormonal regulators, and our recent finding of insulin and insulin receptors throughout …

Insulin and insulin receptors in rodent brain

J Havrankova, M Brownstein, J Roth - Diabetologia, 1981 - Springer
While insulin effects on the central nervous system (CNS) mediated through hypoglycaemia
are well known, direct insulin effects on the CNS remain controversial. Recently, we found …

The evolutionary origins of hormones, neurotransmitters, and other extracellular chemical messengers: implications for mammalian biology

…, MA Lesniak, J Havrankova - … England Journal of …, 1982 - Mass Medical Soc
IN the past, each hormonal peptide was traditionally considered a unique product of a
single cell type that was localized in distribution to a limited region of the body known as an …

Calcium is essential in normalizing intolerance to glucose that accompanies vitamin D depletion in vivo

C Beaulieu, R Kestekian, J Havrankova… - Diabetes, 1993 - Am Diabetes Assoc
Vitamin D is essential for normal insulin secretion in vivo and in vitro. The differential effect of
calcium and of the vitamin D endocrine system in the insulin response to secretagogues is …

Insulin is ubiquitous in extrapancreatic tissues of rats and humans.

JL Rosenzweig, J Havrankova… - Proceedings of the …, 1980 - National Acad Sciences
Insulin has been detected, at levels higher than those in plasma, in a broad range of
extrapancreatic tissues in both rats and humans. Rat liver insulin was shown to be indistinguishable …

Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis

…, J Bertrand, B Feuerstein, J Javurek, J Havrankova… - Journal of …, 2019 - Elsevier
Despite the advances in the treatment of rheumatoid arthritis (RA) achieved in the last few
years, several patients are diagnosed late, do not respond to or have to stop therapy because …

Blood glucose measurements during symptomatic episodes in patients with suspected postprandial hypoglycemia

J Palardy, J Havrankova, R Lepage… - … England Journal of …, 1989 - Mass Medical Soc
Postprandial (reactive) hypoglycemia is a controversial disorder because its symptoms are
not specific, the presence of symptoms often correlates weakly with blood glucose …

Flavones inhibit the activity of AKR1B10, a promising therapeutic target for cancer treatment

…, K Musilek, T Lundova, J Havrankova… - Journal of natural …, 2015 - ACS Publications
AKR1B10 is an NADPH-dependent reductase that plays an important function in several
physiological reactions such as the conversion of retinal to retinol, reduction of isoprenyl …