Multiple sclerosis is a neurodegenerative disease characterized by episodes of autoimmune
attack of oligodendrocytes leading to demyelination and progressive functional deficits. …

Loss of CXCL12, a leukocyte localizing cue, from abluminal surfaces of the blood–brain barrier
occurs in multiple sclerosis (MS) lesions. However, the mechanisms and consequences …

Multiple sclerosis (MS) is characterized by episodes of inflammatory demyelination with
progressive failure of remyelination. Prior studies using murine models of MS indicate that …

Rationale: Prostacyclin analogs, used to treat idiopathic pulmonary arterial hypertension (IPAH),
are assumed to work through prostacyclin (IP) receptors linked to cyclic AMP (cAMP) …

Type I interferons (IFN-α/β) control viral infection by triggering the expression of genes that
restrict transcription, translation, replication, and assembly. Many viruses induce IFN …

Background Due to problems of publication bias and selective reporting, the ICMJE requires
prospective registration of all clinical trials with an appropriate registry before the first …

Myelin, a dielectric sheath that wraps large axons in the central and peripheral nervous
systems, is essential for proper conductance of axon potentials. In multiple sclerosis (MS), …

The Content Based Image retrieval (CBIR) is a very important for retrieving the most visual
relevant images from the large image database. The various low level features are extracted …

Background— Pulmonary hypertension (PH) is a life-threatening disorder characterized by
increased pulmonary artery pressure, remodeling of the pulmonary vasculature, and right …

Current treatment modalities for the neurodegenerative disease multiple sclerosis (MS) use
disease-modifying immunosuppressive compounds but do not promote repair. Although …