Pollution is the largest environmental cause of disease and premature death in the world
today. Diseases caused by pollution were responsible for an estimated 9 million premature …

Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict
cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. …

Base excision repair (BER), as initiated by at least seven different DNA glycosylases or by
enzymes that cleave DNA at abasic sites, executes the repair of a wide variety of DNA …

Protein kinases control cellular decision processes by phosphorylating specific substrates.
Thousands of in vivo phosphorylation sites have been identified, mostly by proteome-wide …

… and trp B, are widely separated from the remaining pathway genes; this gene pair is regulated
through induction by the substrate, indoleglycerol phosphate, rather than repression by L-…

Chronic inflammation increases cancer risk. While it is clear that cell signaling elicited by
inflammatory cytokines promotes tumor development, the impact of DNA damage production …

… complex (l-3). One of the goals of the present x-ray analysis is to understand how electron
transfer … or poly-L-lysine compete with cytochrome c for the oxidase. with certain key regions or …

… These experiments revealed that the expected building blocks l-[2,3- 13 C 2 ]Ala, l-[1- 13
C]Met, [1,2- 13 C 2 ]Gly, and l-[1- 13 C]Cys were incorporated into the two adducts (figs. S4 to S8…

DNA chip technology enables simultaneous examination of how ≈6,200 Saccharomyces
cerevisiae gene transcript levels, representing the entire genome, respond to environmental …

In vitro models of the liver using isolated primary hepatocytes have been used as screens
for measuring the metabolism, toxicity and efficacy of xenobiotics, for studying hepatocyte …