User profiles for L. Samson
Leona D. SamsonProfessor Emerita, Biological Engineering, Biology MIT Verified email at mit.edu Cited by 24877 |
The Lancet Commission on pollution and health
…, J Ramesh, J Rockström, C Salinas, LD Samson… - The lancet, 2018 - thelancet.com
Pollution is the largest environmental cause of disease and premature death in the world
today. Diseases caused by pollution were responsible for an estimated 9 million premature …
today. Diseases caused by pollution were responsible for an estimated 9 million premature …
Balancing repair and tolerance of DNA damage caused by alkylating agents
Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict
cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. …
cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. …
Base excision repair in yeast and mammals
A Memisoglu, L Samson - Mutation Research/Fundamental and Molecular …, 2000 - Elsevier
Base excision repair (BER), as initiated by at least seven different DNA glycosylases or by
enzymes that cleave DNA at abasic sites, executes the repair of a wide variety of DNA …
enzymes that cleave DNA at abasic sites, executes the repair of a wide variety of DNA …
[HTML][HTML] Systematic discovery of in vivo phosphorylation networks
Protein kinases control cellular decision processes by phosphorylating specific substrates.
Thousands of in vivo phosphorylation sites have been identified, mostly by proteome-wide …
Thousands of in vivo phosphorylation sites have been identified, mostly by proteome-wide …
A new pathway for DNA repair in Escherichia coli
L Samson, J Cairns - Nature, 1977 - nature.com
… and trp B, are widely separated from the remaining pathway genes; this gene pair is regulated
through induction by the substrate, indoleglycerol phosphate, rather than repression by L-…
through induction by the substrate, indoleglycerol phosphate, rather than repression by L-…
[HTML][HTML] DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice
Chronic inflammation increases cancer risk. While it is clear that cell signaling elicited by
inflammatory cytokines promotes tumor development, the impact of DNA damage production …
inflammatory cytokines promotes tumor development, the impact of DNA damage production …
Ferricytochrome c: I. general features of the horse and bonito proteins at 2.8 A resolution
…, T Takano, D Eisenberg, OB Kallai, L Samson… - Journal of Biological …, 1971 - Elsevier
… complex (l-3). One of the goals of the present x-ray analysis is to understand how electron
transfer … or poly-L-lysine compete with cytochrome c for the oxidase. with certain key regions or …
transfer … or poly-L-lysine compete with cytochrome c for the oxidase. with certain key regions or …
The human gut bacterial genotoxin colibactin alkylates DNA
… These experiments revealed that the expected building blocks l-[2,3- 13 C 2 ]Ala, l-[1- 13
C]Met, [1,2- 13 C 2 ]Gly, and l-[1- 13 C]Cys were incorporated into the two adducts (figs. S4 to S8…
C]Met, [1,2- 13 C 2 ]Gly, and l-[1- 13 C]Cys were incorporated into the two adducts (figs. S4 to S8…
Global response of Saccharomyces cerevisiae to an alkylating agent
SA Jelinsky, LD Samson - Proceedings of the National …, 1999 - National Acad Sciences
DNA chip technology enables simultaneous examination of how ≈6,200 Saccharomyces
cerevisiae gene transcript levels, representing the entire genome, respond to environmental …
cerevisiae gene transcript levels, representing the entire genome, respond to environmental …
A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction
In vitro models of the liver using isolated primary hepatocytes have been used as screens
for measuring the metabolism, toxicity and efficacy of xenobiotics, for studying hepatocyte …
for measuring the metabolism, toxicity and efficacy of xenobiotics, for studying hepatocyte …