Pilot studies for phase III trials - which are comparative randomized trials designed to
provide preliminary evidence on the clinical efficacy of a drug or intervention - are routinely …

… These included the Living Overview of the Evidence (L-OVE) COVID-19 Repository by the
Epistemonikos Foundation15 and the Systematic and Living Map on COVID-19 Evidence by …

We describe a framework for defining pilot and feasibility studies focusing on studies conducted
in preparation for a randomised controlled trial. To develop the framework, we undertook …

The Consolidated Standards of Reporting Trials (CONSORT) statement is a guideline designed
to improve the transparency and quality of the reporting of randomised controlled trials (…

Context Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung
injury and acute respiratory distress syndrome. Instituting additional strategies to open …

Background Mobile (cell) phone communication has been suggested as a method to improve
delivery of health services. However, data on the effects of mobile health technology on …

BACKGROUND: Obesity is a common health problem that requires a long-term care
approach. We systematically reviewed long-term (≥ 2 y) studies investigating dietary/lifestyle, …

… For a fourth-generation troponin T assay (Roche Diagnostics, Mannheim, Germany), this
was 0.04 µg/l or more and for creatine kinase-MB 8.8 ng/ml or more. These definitions are …

Background Recent evidence indicates a potential therapeutic role of fluvoxamine for
COVID-19. In the TOGETHER trial for acutely symptomatic patients with COVID-19, we aimed to …

Background Sensitivity analyses play a crucial role in assessing the robustness of the findings
or conclusions based on primary analyses of data in clinical trials. They are a critical way …