Intravenous immunoglobulin use in patients with toxic epidermal necrolysis and Stevens-Johnson syndrome

N Mittmann, B Chan, S Knowles, L Cosentino… - American journal of …, 2006 - Springer
Intravenous immunoglobulin (IVIg) has been proposed as a treatment for toxic epidermal
necrolysis (TEN) and Stevens-Johnson syndrome (SJS). A comprehensive search of the …

Paternally transmitted chromosomal aberrations in mouse zygotes determine their embryonic fate

F Marchetti, JB Bishop, L Cosentino… - Biology of …, 2004 - academic.oup.com
The developmental consequences of chromosomal aberrations in embryos include
spontaneous abortions, morphological defects, inborn abnormalities, and genetic/chromosomal …

The cII locus in the MutaMouse System

RR Swiger, L Cosentino, N Shima… - Environmental and …, 1999 - Wiley Online Library
Here, we report the first application and characterization of the cII locus as a mutational target
for use with the Muta ™ Mouse system for quantifying somatic mutations in vivo. This locus …

α1-Antitrypsin deficiency: Forgotten etiology

A Kaplan, L Cosentino - Canadian Family Physician, 2010 - cfp.ca
… Alan Kaplan and Lidia Cosentino … Dr Cosentino participated in the literature search and
helped to revise the article … Dr Cosentino is an employee of Talecris Biotherapeutics, makers of …

System issues: A test for neutrality of mutations of the lacZ transgene

L Cosentino, JA Heddle - Environmental and molecular …, 1996 - Wiley Online Library
Neutral mutations are stable alterations in DNA that are neither beneficial nor damaging to
the cell. Once a mutation is fixed in the DNA, the mutant frequency should increase to its …

Differential mutation of transgenic and endogenous loci in vivo

L Cosentino, JA Heddle - Mutation Research/Fundamental and Molecular …, 2000 - Elsevier
Although chemicals usually induce very similar frequencies of mutations in transgenes and
endogenous genes in vivo when given acutely, chronic exposure to N-ethyl-N-nitrosourea (…

Further characterization and validation of gpt delta transgenic mice for quantifying somatic mutations in vivo

RR Swiger, L Cosentino, KI Masumura… - Environmental and …, 2001 - Wiley Online Library
The utility of any mutation assay depends on its characteristics, which are best discovered
using model mutagens. To this end, we report further on the characteristics of the lambda-…

The relationships among stem cells, crypts, and villi in the small intestine of mice as determined by mutation tagging

L Cosentino, P Shaver‐Walker… - Developmental …, 1996 - Wiley Online Library
The number of stem cells that maintain a crypt of the small intestine is uncertain. Although the
number of stem cells per crypt had been thought to be 10–20, current estimates indicate a …

A comparison of the effects of diverse mutagens at the lacZ transgene and Dlb-1 locus in vivo

L Cosentino, JA Heddle - Mutagenesis, 1999 - academic.oup.com
Transgenic assays permit the detection of mutations in any tissue, whereas endogenous
mutations can be measured in very few. For this reason comparisons between these loci when …

Effects of extended chronic exposures on endogenous and transgenic loci: Implications for low‐dose extrapolations

L Cosentino, JA Heddle - Environmental and molecular …, 1999 - Wiley Online Library
Although transgenic and endogenous loci generally respond alike to acute mutagenic
exposures, those loci that have been tested respond differently to daily or continuous exposures. …