Human pluripotent stem cells have the potential to provide comprehensive model systems
for the earliest stages of human ontogenesis. To serve in this capacity, these cells must …

Differentiation methods for human induced pluripotent stem cells (hiPSCs) typically yield
progeny from multiple tissue lineages, limiting their use for drug testing and autologous cell …

Best disease (BD) is an inherited degenerative disease of the human macula that results in
progressive and irreversible central vision loss. It is caused by mutations in the retinal …

Purpose.: We sought to determine if human induced pluripotent stem cells (iPSCs) derived
from blood could produce optic vesicle–like structures (OVs) with the capacity to stratify and …

Recent studies indicate that NF-E2 related factor 2 (Nrf2) is a substrate for the ubiquitin-proteasome
pathway. The present study is aimed to determine whether increased protein …

Bacterial cell wall peptidoglycan is a dynamic structure requiring hydrolysis to allow cell wall
growth and division. Staphylococcus aureus has many known and putative peptidoglycan …

Dehydroepiandrosterone (DHEA) is a neurosteroid with potential effects on neurogenesis
and neuronal survival in humans. However, most studies on DHEA have been performed in …

Excitatory amino acids such as glutamate play important roles in the central nervous system.
We previously demonstrated that a neurosteroid, dehydroepiandrosterone (DHEA), has …

Purpose.: To determine the effects of serial expansion on the cellular, molecular, and
functional properties of human iPS cell (hiPSC)-derived RPE cultures. Methods.: Fibroblasts …

Human induced pluripotent stem cells (hiPSCs) have been shown to differentiate along the
retinal lineage in a manner that mimics normal mammalian development. Under certain …