The role of bacterial biofilms in ocular infections

ME Zegans, HI Becker, J Budzik, G O'Toole - DNA and cell biology, 2002 - liebertpub.com
There is increasing evidence that bacterial biofilms play a role in a variety of ocular infections.
Bacterial growth is characterized as a biofilm when bacteria attach to a surface and/or to …

Ocular manifestations of hepatitis C virus infection

ME Zegans, W Anninger, C Chapman… - Current opinion in …, 2002 - journals.lww.com
Approximately 3.6 million persons in the United States are infected with the hepatitis C virus
(HCV), a condition with both hepatic and extrahepatic sequelae. Although no …

The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole

…, CE Oldenburg, KJ Ray, ME Zegans… - JAMA …, 2013 - jamanetwork.com
Objective To compare topical natamycin vs voriconazole in the treatment of filamentous
fungal keratitis. Methods This phase 3, double-masked, multicenter trial was designed to …

Heparin Stimulates Staphylococcus aureus Biofilm Formation

…, ML Graber, SE Buckingham, ME Zegans… - Infection and …, 2005 - Am Soc Microbiol
Heparin, known for its anticoagulant activity, is commonly used in catheter locks. Staphylococcus
aureus, a versatile human and animal pathogen, is commonly associated with catheter-…

Interaction between Bacteriophage DMS3 and Host CRISPR Region Inhibits Group Behaviors of Pseudomonas aeruginosa

ME Zegans, JC Wagner, KC Cady… - Journal of …, 2009 - Am Soc Microbiol
Bacteriophage infection has profound effects on bacterial biology. Clustered regular interspaced
short palindromic repeats (CRISPRs) and cas (CRISPR-associated) genes are found in …

Primary structure of the 175K Plasmodium falciparum erythrocyte binding antigen and identification of a peptide which elicits antibodies that inhibit malaria merozoite …

…, FW Klotz, JM Carter, D Camus, ME Zegans… - The Journal of cell …, 1990 - rupress.org
Zegans' present address is University of California at San Francisco Medical School, San …
Perkins, ME 1984. Surface proteins of Plasmodium falciparum merozoites binding to the …

Evidence for Two Flagellar Stators and Their Role in the Motility of Pseudomonas aeruginosa

CM Toutain, ME Zegans, GA O'Toole - Journal of bacteriology, 2005 - Am Soc Microbiol
Pseudomonas aeruginosa is a ubiquitous bacterium capable of twitching, swimming, and
swarming motility. In this study, we present evidence that P. aeruginosa has two flagellar …

Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT)

…, CE Oldenburg, SM Lee, ME Zegans… - Archives of …, 2012 - jamanetwork.com
Objective To determine whether there is a benefit in clinical outcomes with the use of topical
corticosteroids as adjunctive therapy in the treatment of bacterial corneal ulcers. Methods …

Comparison of natamycin and voriconazole for the treatment of fungal keratitis

…, SM Lee, SD McLeod, ME Zegans… - Archives of …, 2010 - jamanetwork.com
Objective To conduct a therapeutic exploratory clinical trial comparing clinical outcomes of
treatment with topical natamycin vs topical voriconazole for fungal keratitis. Methods The …

Paradox of complex diversity: Challenges in the diagnosis and management of bacterial keratitis

…, S Das, J Chodosh, N Sharma, ME Zegans… - Progress in Retinal and …, 2022 - Elsevier
Bacterial keratitis continues to be one of the leading causes of corneal blindness in the
developed as well as the developing world, despite swift progress since the dawn of the “anti-…