[HTML][HTML] The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility Index

…, O Levine, C Ribic, AO Molnar, ND Dattani… - Journal of clinical …, 2014 - Elsevier
Objectives A P-value <0.05 is one metric used to evaluate the results of a randomized controlled
trial (RCT). We wondered how often statistically significant results in RCTs may be lost …

The influence of study characteristics on reporting of subgroup analyses in randomised controlled trials: systematic review

…, J Truong, ND Dattani, SD Walter, D Heels-Ansdell… - Bmj, 2011 - bmj.com
Objective To investigate the impact of industry funding on reporting of subgroup analyses in
randomised controlled trials. Design Systematic review. Data sources Medline. Study …

Metoprolol reduces cerebral tissue oxygen tension after acute hemodilution in rats

…, G Tait, J Yu, E Liu, M Noronha, ND Dattani… - The Journal of the …, 2009 - pubs.asahq.org
Background Perioperative beta-blockade and anemia are independent predictors of increased
stroke and mortality by undefined mechanisms. This study investigated the effect of beta-…

Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia

…, MH El-Beheiry, ND Dattani… - Proceedings of the …, 2011 - National Acad Sciences
Cells sense and respond to changes in oxygen concentration through gene regulatory
processes that are fundamental to survival. Surprisingly, little is known about how anemia affects …

Emergency department volume and outcomes for patients after chest pain assessment

DT Ko, ND Dattani, PC Austin, MJ Schull… - … Quality and Outcomes, 2018 - Am Heart Assoc
Background: Chest pain is one of the most common reasons for emergency department (ED)
visits in developed countries. Whether higher volume EDs have better outcomes, …

[PDF][PDF] Reassessing the risk of hemodilutional anemia: Some new pieces to an old puzzle

AKY Tsui, ND Dattani, PA Marsden… - … /Journal canadien d' …, 2010 - researchgate.net
Conclusions Evidence continues to demonstrate that anemia increases morbidity and mortality,
possibly via hypoxic mechanisms. A potential strategy for assessing ‘‘anemic stress’’was …

Effect of comorbidities and medications on frequency of primary care visits among older patients

T Hu, ND Dattani, KA Cox, B Au, L Xu, D Melady… - Canadian Family …, 2017 - cfp.ca
Objective To determine if comorbidities and high-risk medications affect the frequency of
family physician visits among older patients. Design Retrospective chart review. Setting …

Setting the Healthcare Agenda

ND Dattani - 2010 - macsphere.mcmaster.ca
In political landscapes around the world, governments have no shortage of healthcare
issues to overcome. With the abundance of decisions to be made and the limited time and …

Perinuclear antineutrophil cytoplasmic antibody–associated vasculitis in an elderly woman

T Hu, ND Dattani, C Pagnoux, R Jain - Canadian Family Physician, 2016 - cfp.ca
(ANCA)–associated vasculitis encompasses 3 conditions: eosinophilic granulomatosis with
polyangiitis (EGPA; formerly named Churg-Strauss syndrome), granulomatosis with …

Staphylococcus aureus-Basic features and treatment

V Vijayakumaran, ND Dattani - 2010 - macsphere.mcmaster.ca
This paper succinctly describes salient characteristics of Staphylococcus aureus, and briefly
outlines how methicillin resistant Staphylococcus aureus is currently treated. One field of …