Psychosocial diagnoses occurring after patients present with fatigue

PR MacKean, M Stewart, HL Maddocks - Canadian Family Physician, 2016 - cfp.ca
Objective To discover the frequency of psychosocial and other diagnoses occurring at the
end of a visit when patients present to their FPs with concerns about fatigue. Design Cross-…

Family Medicine Forum Research Proceedings 2016Do urine cultures in the emergency department change management of young women with symptoms of …

…, G Halas, A Schultz, M Zeng, PR MacKean… - Canadian Family …, 2017 - cfp.ca
Context Current guidelines do not recommend routine use of urinary cultures for managing
uncomplicated urinary tract infections (UTIs) in premenopausal, nonpregnant women. …

[HTML][HTML] Hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma

…, J Thomson, M Churchman, T Rye, M Mackean… - Gynecologic …, 2019 - Elsevier
… Here we assess the expression levels of progesterone receptor (PR), estrogen receptor alpha
(… Ten-year survival for stage II PR high and PR low cases was 94.1% and 42.4%. ER high …

[HTML][HTML] Integrated molecular characterisation of endometrioid ovarian carcinoma identifies opportunities for stratification

…, I Croy, T Rye, C Bartos, F Nussey, M Mackean… - NPJ Precision …, 2021 - nature.com
… and oestrogen receptor (PR and ER) … : PR-high (PR + /ER + , PR + /ER−) cases were
predominantly CTNNB1-mutant (73.2% vs 18.4%, P < 0.001), while PR-low (PR−/ER + , PR−/ER−) …

[PDF][PDF] Phase I and pharmacologic study of intermittent twice-daily oral therapy with capecitabine in patients with advanced and/or metastatic cancer.

M Mackean, A Planting, C Twelves… - Journal of Clinical …, 1998 - researchgate.net
… treated with local radiotherapy only, had a PR in liver metastases after two cycles of … -FU,
had a PR after four cycles that was maintained for 41 weeks on treatment. The third PR was in a …

Antiestrogen therapy is active in selected ovarian cancer cases: the use of letrozole in estrogen receptor–positive patients

JF Smyth, C Gourley, G Walker, MJ MacKean… - Clinical Cancer …, 2007 - AACR
Purpose: To evaluate the efficacy of the aromatase inhibitor letrozole in preselected estrogen
receptor (ER)–positive relapsed epithelial ovarian cancer patients and to identify markers …

[HTML][HTML] Short-term safety outcomes of mastectomy and immediate implant-based breast reconstruction with and without mesh (iBRA): a multicentre, prospective …

…, I Hamo, C Harding-Mackean… - The Lancet …, 2019 - thelancet.com
Background Use of biological or synthetic mesh might improve outcomes of immediate
implant-based breast reconstruction—breast reconstruction with implants or expanders at the …

[HTML][HTML] A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in …

…, RH Wilson, S Pledge, J Paul, M Mackean… - British journal of …, 2014 - nature.com
… The primary end point was defined as any response (PR or CR) in patients with methylated
… Overall RR was any response (PR or CR) in any of the patients as determined by RECIST …

Endocrine treatment of high grade serous ovarian carcinoma; quantification of efficacy and identification of response predictors

…, JD Towler, X Yan, T Rye, C Dawson, MJ Mackean… - Gynecologic …, 2019 - Elsevier
… ER and PR expression levels were retrospectively analysed and patients with ER
histoscore ≥150 and PR histoscore ≥70 were found to have a 64% disease stabilisation rate …

Are we over-doctoring?: Thoughts on bedside manner

PR MacKean - Canadian Family Physician, 2008 - cfp.ca
Twenty-four years ago, fresh out of a family medicine residency and eager to apply my trade,
I entered a previously established practice in a small town in Prince Edward Island. My …