User profiles for Paul L Beck

Paul L. Beck

Professor Medicine, Division of Gastroenterology, University of Calgary.
Verified email at ucalgary.ca
Cited by 23775

Hapten-induced model of chronic inflammation and ulceration in the rat colon

GP Morris, PL Beck, MS Herridge, WT Depew… - Gastroenterology, 1989 - Elsevier
We have developed a simple and reproducible rat model of chronic colonic inflammation by
the intraluminal instillation of a solution containing a “barrier breaker” and a. hapten. …

Intravascular danger signals guide neutrophils to sites of sterile inflammation

…, SA Hirota, I Slaba, CCM Waterhouse, PL Beck… - Science, 2010 - science.org
Neutrophils are recruited from the blood to sites of sterile inflammation, where they contribute
to wound healing but may also cause tissue damage. By using spinning disk confocal …

Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors

…, IM Rosenberg, SL Brandwein, PL Beck… - The Journal of …, 2000 - journals.aai.org
LPS elicits several immediate proinflammatoy responses in peripheral blood leukocytes via
a recently described pathway including CD14, Toll-like receptors (TLR), serine-threonine …

The NLRP3 inflammasome promotes renal inflammation and contributes to CKD

…, K Trpkov, BR Hemmelgarn, PL Beck… - Journal of the …, 2010 - journals.lww.com
Inflammation significantly contributes to the progression of chronic kidney disease (CKD).
Inflammasome-dependent cytokines, such as IL-1β and IL-18, play a role in CKD, but their …

Invasive potential of gut mucosa-derived Fusobacterium nucleatum positively correlates with IBD status of the host

J Strauss, GG Kaplan, PL Beck, K Rioux… - Inflammatory bowel …, 2011 - academic.oup.com
Background Fusobacterium nucleatum is a heterogeneous oral pathogen that is also a common
resident of the human gut mucosa. Given that some strains of F. nucleatum are known to …

Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease

JL Wallace, WK MacNaughton, GP Morris, PL Beck - Gastroenterology, 1989 - Elsevier
The role of leukotrienes in the pathogenesis of chronic colitis was investigated using a rat
model. Ulceration and inflammation of the distal colon was initiated by the intracolonic …

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

…, D Muruve, JA MacDonald, PL Beck - Inflammatory bowel …, 2011 - academic.oup.com
Background Attenuated innate immune responses to the intestinal microbiota have been
linked to the pathogenesis of Crohn's disease (CD). Recent genetic studies have revealed that …

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

…, JA MacDonald, DA Muruve, DM McKay, PL Beck… - Nature medicine, 2012 - nature.com
Inflammatory bowel diseases (IBDs) are chronic relapsing and remitting conditions associated
with long-term gut dysfunction resulting from alterations to the enteric nervous system and …

In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice

…, KS Parhar, MJG Johnston, N Van Rooijen, PL Beck… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Infection with the rat tapeworm Hymenolepis diminuta reduces the
severity of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice. Infection with H …

Gallbladder polyps: epidemiology, natural history and management

RP Myers, EA Shaffer, PL Beck - Canadian Journal of …, 2002 - hindawi.com
Polypoid lesions of the gallbladder affect approximately 5% of the adult population. Most
affected individuals are asymptomatic, and their gallbladder polyps are detected during …