User profiles for Paul L Beck
Paul L. BeckProfessor Medicine, Division of Gastroenterology, University of Calgary. Verified email at ucalgary.ca Cited by 23775 |
Hapten-induced model of chronic inflammation and ulceration in the rat colon
GP Morris, PL Beck, MS Herridge, WT Depew… - Gastroenterology, 1989 - Elsevier
We have developed a simple and reproducible rat model of chronic colonic inflammation by
the intraluminal instillation of a solution containing a “barrier breaker” and a. hapten. …
the intraluminal instillation of a solution containing a “barrier breaker” and a. hapten. …
Intravascular danger signals guide neutrophils to sites of sterile inflammation
Neutrophils are recruited from the blood to sites of sterile inflammation, where they contribute
to wound healing but may also cause tissue damage. By using spinning disk confocal …
to wound healing but may also cause tissue damage. By using spinning disk confocal …
Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors
…, IM Rosenberg, SL Brandwein, PL Beck… - The Journal of …, 2000 - journals.aai.org
LPS elicits several immediate proinflammatoy responses in peripheral blood leukocytes via
a recently described pathway including CD14, Toll-like receptors (TLR), serine-threonine …
a recently described pathway including CD14, Toll-like receptors (TLR), serine-threonine …
The NLRP3 inflammasome promotes renal inflammation and contributes to CKD
Inflammation significantly contributes to the progression of chronic kidney disease (CKD).
Inflammasome-dependent cytokines, such as IL-1β and IL-18, play a role in CKD, but their …
Inflammasome-dependent cytokines, such as IL-1β and IL-18, play a role in CKD, but their …
Invasive potential of gut mucosa-derived Fusobacterium nucleatum positively correlates with IBD status of the host
Background Fusobacterium nucleatum is a heterogeneous oral pathogen that is also a common
resident of the human gut mucosa. Given that some strains of F. nucleatum are known to …
resident of the human gut mucosa. Given that some strains of F. nucleatum are known to …
Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease
The role of leukotrienes in the pathogenesis of chronic colitis was investigated using a rat
model. Ulceration and inflammation of the distal colon was initiated by the intracolonic …
model. Ulceration and inflammation of the distal colon was initiated by the intracolonic …
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
…, D Muruve, JA MacDonald, PL Beck - Inflammatory bowel …, 2011 - academic.oup.com
Background Attenuated innate immune responses to the intestinal microbiota have been
linked to the pathogenesis of Crohn's disease (CD). Recent genetic studies have revealed that …
linked to the pathogenesis of Crohn's disease (CD). Recent genetic studies have revealed that …
Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis
Inflammatory bowel diseases (IBDs) are chronic relapsing and remitting conditions associated
with long-term gut dysfunction resulting from alterations to the enteric nervous system and …
with long-term gut dysfunction resulting from alterations to the enteric nervous system and …
In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice
…, KS Parhar, MJG Johnston, N Van Rooijen, PL Beck… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Infection with the rat tapeworm Hymenolepis diminuta reduces the
severity of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice. Infection with H …
severity of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice. Infection with H …
Gallbladder polyps: epidemiology, natural history and management
RP Myers, EA Shaffer, PL Beck - Canadian Journal of …, 2002 - hindawi.com
Polypoid lesions of the gallbladder affect approximately 5% of the adult population. Most
affected individuals are asymptomatic, and their gallbladder polyps are detected during …
affected individuals are asymptomatic, and their gallbladder polyps are detected during …