User profiles for R. D. Goldman

Robert D. Goldman

Professor, Feinberg School of Medicine, Northwestern University
Verified email at northwestern.edu
Cited by 44766

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome

RD Goldman, DK Shumaker… - Proceedings of the …, 2004 - National Acad Sciences
Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disorder, commonly
caused by a point mutation in the lamin A gene that results in a protein lacking 50 aa near the …

[HTML][HTML] Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition

MG Mendez, SI Kojima, RD Goldman - The FASEB Journal, 2010 - ncbi.nlm.nih.gov
… I., Goldman, RD Vimentin induces changes in cell shape, motility, and adhesion during the
epithelial to … Goldman R D. The role of three cytoplasmic fibers in BHK-21 cell motility. I. …

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

…, DK Shumaker, L Solimando, RD Goldman - Genes & …, 2008 - genesdev.cshlp.org
Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but are …

Nuclear lamins: building blocks of nuclear architecture

RD Goldman, Y Gruenbaum, RD Moir… - Genes & …, 2002 - genesdev.cshlp.org
Nuclear lamins were initially identified as the major components of the nuclear lamina, a
proteinaceous layer found at the interface between chromatin and the inner nuclear membrane (…

The nuclear lamina comes of age

Y Gruenbaum, A Margalit, RD Goldman… - … reviews Molecular cell …, 2005 - nature.com
Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins,
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization, …

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

…, FS Collins, T Jenuwein, RD Goldman - Proceedings of the …, 2006 - National Acad Sciences
The premature aging disease Hutchinson–Gilford Progeria Syndrome (HGPS) is caused by
a mutant lamin A (LAΔ50). Nuclei in cells expressing LAΔ50 are abnormally shaped and …

The A-and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

…, M Kinjo, T Cremer, RD Goldman - Genes & …, 2008 - genesdev.cshlp.org
The nuclear lamins function in the regulation of replication, transcription, and epigenetic
modifications of chromatin. However, the mechanisms responsible for these lamin functions are …

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are …

…, G Litwack, RD Moir, RD Goldman… - Proceedings of the …, 1996 - National Acad Sciences
Although proteases related to the interleukin 1 beta-converting enzyme (ICE) are known to
be essential for apoptotic execution, the number of enzymes involved, their substrate …

Nuclear lamins A and B1: different pathways of assembly during nuclear envelope formation in living cells

RD Moir, M Yoon, S Khuon, RD Goldman - The Journal of cell biology, 2000 - rupress.org
At the end of mitosis, the nuclear lamins assemble to form the nuclear lamina during nuclear
envelope formation in daughter cells. We have fused A- and B-type nuclear lamins to the …

Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia

M Schoumacher, RD Goldman, D Louvard… - Journal of Cell …, 2010 - rupress.org
Invasive cancer cells are believed to breach the basement membrane (BM) using specialized
protrusions called invadopodia. We found that the crossing of a native BM is a three-stage …