User profiles for R. D. Goldman
Robert D. GoldmanProfessor, Feinberg School of Medicine, Northwestern University Verified email at northwestern.edu Cited by 44766 |
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome
RD Goldman, DK Shumaker… - Proceedings of the …, 2004 - National Acad Sciences
Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disorder, commonly
caused by a point mutation in the lamin A gene that results in a protein lacking 50 aa near the …
caused by a point mutation in the lamin A gene that results in a protein lacking 50 aa near the …
[HTML][HTML] Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition
MG Mendez, SI Kojima, RD Goldman - The FASEB Journal, 2010 - ncbi.nlm.nih.gov
… I., Goldman, RD Vimentin induces changes in cell shape, motility, and adhesion during the
epithelial to … Goldman R D. The role of three cytoplasmic fibers in BHK-21 cell motility. I. …
epithelial to … Goldman R D. The role of three cytoplasmic fibers in BHK-21 cell motility. I. …
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
…, DK Shumaker, L Solimando, RD Goldman - Genes & …, 2008 - genesdev.cshlp.org
Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but are …
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but are …
Nuclear lamins: building blocks of nuclear architecture
RD Goldman, Y Gruenbaum, RD Moir… - Genes & …, 2002 - genesdev.cshlp.org
Nuclear lamins were initially identified as the major components of the nuclear lamina, a
proteinaceous layer found at the interface between chromatin and the inner nuclear membrane (…
proteinaceous layer found at the interface between chromatin and the inner nuclear membrane (…
The nuclear lamina comes of age
Y Gruenbaum, A Margalit, RD Goldman… - … reviews Molecular cell …, 2005 - nature.com
Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins,
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization, …
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization, …
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
…, FS Collins, T Jenuwein, RD Goldman - Proceedings of the …, 2006 - National Acad Sciences
The premature aging disease Hutchinson–Gilford Progeria Syndrome (HGPS) is caused by
a mutant lamin A (LAΔ50). Nuclei in cells expressing LAΔ50 are abnormally shaped and …
a mutant lamin A (LAΔ50). Nuclei in cells expressing LAΔ50 are abnormally shaped and …
The A-and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription
The nuclear lamins function in the regulation of replication, transcription, and epigenetic
modifications of chromatin. However, the mechanisms responsible for these lamin functions are …
modifications of chromatin. However, the mechanisms responsible for these lamin functions are …
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are …
…, G Litwack, RD Moir, RD Goldman… - Proceedings of the …, 1996 - National Acad Sciences
Although proteases related to the interleukin 1 beta-converting enzyme (ICE) are known to
be essential for apoptotic execution, the number of enzymes involved, their substrate …
be essential for apoptotic execution, the number of enzymes involved, their substrate …
Nuclear lamins A and B1: different pathways of assembly during nuclear envelope formation in living cells
RD Moir, M Yoon, S Khuon, RD Goldman - The Journal of cell biology, 2000 - rupress.org
At the end of mitosis, the nuclear lamins assemble to form the nuclear lamina during nuclear
envelope formation in daughter cells. We have fused A- and B-type nuclear lamins to the …
envelope formation in daughter cells. We have fused A- and B-type nuclear lamins to the …
Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia
Invasive cancer cells are believed to breach the basement membrane (BM) using specialized
protrusions called invadopodia. We found that the crossing of a native BM is a three-stage …
protrusions called invadopodia. We found that the crossing of a native BM is a three-stage …