Evolution and 15-year effect of a pan-Canadian training program: Transdisciplinary Understanding and Training on Research–Primary Health Care

AL Terry, JB Brown, R Van Hoorn, M Stewart… - Canadian Family …, 2018 - cfp.ca
Addressing complex primary health care (PHC) questions requires the knowledge, skills,
and effective collaboration of interdisciplinary research teams. 1 The Transdisciplinary …

[HTML][HTML] Flavonoids: a review of probable mechanisms of action and potential applications

RJ Nijveldt, ELS Van Nood, DEC Van Hoorn… - The American journal of …, 2001 - Elsevier
The aim of this review, a summary of the putative biological actions of flavonoids, was to
obtain a further understanding of the reported beneficial health effects of these substances. …

[HTML][HTML] Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism

…, O van Tellingen, JWA van der Hoorn… - The Journal of …, 2007 - Am Soc Clin Investig
Cytochrome P450 3A (CYP3A) enzymes constitute an important detoxification system that
contributes to primary metabolism of more than half of all prescribed medications. To …

Performance engineering for microservices: research challenges and directions

R Heinrich, A Van Hoorn, H Knoche, F Li… - Proceedings of the 8th …, 2017 - dl.acm.org
Microservices complement approaches like DevOps and continuous delivery in terms of
software architecture. Along with this architectural style, several important deployment …

Modeling complex user behavior with the palladio component model

C Vögele, H Robert, H Robert, A van Hoorn, H Krcmar - 2015 - oceanrep.geomar.de
The specification of workloads is required in order to evaluate performance characteristics of
application systems using performance prediction approaches like the Palladio Component …

[HTML][HTML] A randomized trial of intravenous alteplase before endovascular treatment for stroke

…, R van den Berg, A van der Hoorn… - New England journal …, 2021 - Mass Medical Soc
Background The value of administering intravenous alteplase before endovascular treatment
(EVT) for acute ischemic stroke has not been studied extensively, particularly in non-Asian …

The chemical compound 'Heatin'stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1‐subfamily of nitrilases

…, NI Martin, RAL van Der Hoorn, S Robert… - The Plant …, 2021 - Wiley Online Library
Temperature passively affects biological processes involved in plant growth. Therefore, it is
challenging to study the dedicated temperature signalling pathways that orchestrate …

Endovascular treatment versus no endovascular treatment after 6–24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in …

…, AA Postma, SD Roosendaal, A van der Hoorn… - The Lancet, 2023 - thelancet.com
Background Endovascular treatment for anterior circulation ischaemic stroke is effective and
safe within a 6 h window. MR CLEAN-LATE aimed to assess efficacy and safety of …

Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre …

…, G Lycklama, FJA Meijer, S Hammer, A van der Hoorn… - The Lancet, 2022 - thelancet.com
Background Aspirin and unfractionated heparin are often used during endovascular stroke
treatment to improve reperfusion and outcomes. However, the effects and risks of anti-…

Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids

DEC Van Hoorn, RJ Nijveldt, PAM Van Leeuwen… - European journal of …, 2002 - Elsevier
The flavonoid family shows a high potential for inhibition of xanthine oxidase. Currently, more
than 4000 flavonoids are known. The data of this study indicate that a planar structure is …