Evolution and 15-year effect of a pan-Canadian training program: Transdisciplinary Understanding and Training on Research–Primary Health Care
Addressing complex primary health care (PHC) questions requires the knowledge, skills,
and effective collaboration of interdisciplinary research teams. 1 The Transdisciplinary …
and effective collaboration of interdisciplinary research teams. 1 The Transdisciplinary …
[HTML][HTML] Flavonoids: a review of probable mechanisms of action and potential applications
RJ Nijveldt, ELS Van Nood, DEC Van Hoorn… - The American journal of …, 2001 - Elsevier
The aim of this review, a summary of the putative biological actions of flavonoids, was to
obtain a further understanding of the reported beneficial health effects of these substances. …
obtain a further understanding of the reported beneficial health effects of these substances. …
[HTML][HTML] Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism
…, O van Tellingen, JWA van der Hoorn… - The Journal of …, 2007 - Am Soc Clin Investig
Cytochrome P450 3A (CYP3A) enzymes constitute an important detoxification system that
contributes to primary metabolism of more than half of all prescribed medications. To …
contributes to primary metabolism of more than half of all prescribed medications. To …
Performance engineering for microservices: research challenges and directions
Microservices complement approaches like DevOps and continuous delivery in terms of
software architecture. Along with this architectural style, several important deployment …
software architecture. Along with this architectural style, several important deployment …
Modeling complex user behavior with the palladio component model
The specification of workloads is required in order to evaluate performance characteristics of
application systems using performance prediction approaches like the Palladio Component …
application systems using performance prediction approaches like the Palladio Component …
[HTML][HTML] A randomized trial of intravenous alteplase before endovascular treatment for stroke
…, R van den Berg, A van der Hoorn… - New England journal …, 2021 - Mass Medical Soc
Background The value of administering intravenous alteplase before endovascular treatment
(EVT) for acute ischemic stroke has not been studied extensively, particularly in non-Asian …
(EVT) for acute ischemic stroke has not been studied extensively, particularly in non-Asian …
The chemical compound 'Heatin'stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1‐subfamily of nitrilases
Temperature passively affects biological processes involved in plant growth. Therefore, it is
challenging to study the dedicated temperature signalling pathways that orchestrate …
challenging to study the dedicated temperature signalling pathways that orchestrate …
Endovascular treatment versus no endovascular treatment after 6–24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in …
…, AA Postma, SD Roosendaal, A van der Hoorn… - The Lancet, 2023 - thelancet.com
Background Endovascular treatment for anterior circulation ischaemic stroke is effective and
safe within a 6 h window. MR CLEAN-LATE aimed to assess efficacy and safety of …
safe within a 6 h window. MR CLEAN-LATE aimed to assess efficacy and safety of …
Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre …
…, G Lycklama, FJA Meijer, S Hammer, A van der Hoorn… - The Lancet, 2022 - thelancet.com
Background Aspirin and unfractionated heparin are often used during endovascular stroke
treatment to improve reperfusion and outcomes. However, the effects and risks of anti-…
treatment to improve reperfusion and outcomes. However, the effects and risks of anti-…
Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids
DEC Van Hoorn, RJ Nijveldt, PAM Van Leeuwen… - European journal of …, 2002 - Elsevier
The flavonoid family shows a high potential for inhibition of xanthine oxidase. Currently, more
than 4000 flavonoids are known. The data of this study indicate that a planar structure is …
than 4000 flavonoids are known. The data of this study indicate that a planar structure is …