Preclinical mechanistic studies have pointed towards RNA interference-mediated off-target
effects as a major driver of hepatotoxicity for GalNAc–siRNA conjugates. Here, we …

Iron deficiency is the most frequent cause of anaemia worldwide. It impairs quality of life,
increases asthenia and can lead to clinical worsening of patients. In addition, iron deficiency …

Basolateral amygdala (BLA) principal cells are capable of driving and antagonizing behaviors
of opposing valence. BLA neurons project to the central amygdala (CeA), which also …

Mesenchymal stem cells (MSCs) are promising candidates for cell-based therapy to treat
several diseases and are compelling to consider as vehicles for delivery of biological agents. …

Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been
approved, but new delivery solutions are needed to target additional organs. Here we show …

Background and study aims: The hemostatic powder TC-325 (Hemospray; Cook Medical,
Winston-Salem, North Carolina, USA) has shown promising results in the treatment of upper …

… Author links open overlay panel Marine Camus MD, PhD 1 , Bertrand Napoléon MD 2 ,
Ariane Vienne MD 3 , Marc Le Rhun MD 4 , Sarah Leblanc MD 1 , Maximilien Barret MD, PhD 1 , …

Objectives Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) using standard
needles has a high diagnostic value in the evaluation of solid pancreatic masses. …

Background Non-occlusive mesenteric ischemia (NOMI) is a common complication and
accounts for a major cause of death in critically ill patients. The diagnosis of NOMI with respect to …

Background: Percutaneous transhepatic biliary drainage (PTBD) is widely performed as a
salvage procedure in patients with unresectable malignant obstruction of the common bile …