Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: an enzymatic Pictet− Spengler reaction

LYP Luk, S Bunn, DK Liscombe, PJ Facchini… - Biochemistry, 2007 - ACS Publications
Norcoclaurine synthase catalyzes an asymmetric Pictet−Spengler condensation of dopamine
and 4-hydroxyphenylacetaldehyde to give (S)-norcoclaurine. This is the first committed …

The Dinuclear Zn (II) Complex Catalyzed Cyclization of a Series of 2-Hydroxypropyl Aryl Phosphate RNA Models: Progressive Change in Mechanism from Rate …

SE Bunn, CT Liu, ZL Lu, AA Neverov… - Journal of the American …, 2007 - ACS Publications
A methoxide-bridged dinuclear Zn(II) complex of 1,3-[N,N‘-bis(1,5,9-triazacyclododecane)]propane
(1-Zn(II) 2 :( - OCH 3 )) was prepared, and its catalysis of the cyclization of a series of …

A Simple DNase Model System Comprising a Dinuclear Zn (II) Complex in Methanol Accelerates the Cleavage of a Series of Methyl Aryl Phosphate Diesters by 1011 …

AA Neverov, CT Liu, SE Bunn, D Edwards… - Journal of the …, 2008 - ACS Publications
The di-Zn(II) complex of 1,3-bis[N 1 ,N 1 ′-(1,5,9-triazacyclododecyl)]propane with an
associated methoxide (3:Zn(II) 2 : − OCH 3 ) was prepared and its catalysis of the methanolysis of …

Attributes and outcomes of end stage liver disease as compared with other noncancer patients admitted to a geriatric palliative care unit

GA Perri, S Bunn, YJ Oh, A Kassam… - Annals of Palliative …, 2016 - apm.amegroups.org
Background: End stage liver disease (ESLD) is increasingly more prevalent as a noncancer
disease to manage in palliative care. Because of the clear lack of a “terminal phase” in ESLD…

Understanding the demographic characteristics and health of medically uninsured patients

S Bunn, P Fleming, D Rzeznikiewiz, FH Leung - Canadian Family Physician, 2013 - cfp.ca
Objective To determine demographic and diagnostic information about the medically uninsured
patient population and compare it with that of the medically insured patient population at …

[BOOK][B] Biomimetic Aminoacylation: Optimization of Reaction Conditions

SE Bunn - 2009 - collectionscanada.gc.ca
Synthesizing proteins containing unnatural amino acids inserted at specific positions within
the protein sequence has been a longstanding goal of biological chemists. This poses …

[CITATION][C] Improved Teeth and Lip Design for Shovel Dipper Performance

S Bunn - 2002 - espace.library.uq.edu.au
Electric mining shovels are the traditional ‘work horses’ in large open pit mining operations
due to their greater size, productivity, reliability and low operating costs. As mining operations …

Lanthanum-mediated Biomimetic Aminoacylation

S Her - 2012 - library-archives.canada.ca
Methods are being developed to produce" designer proteins" from unnatural amino acids
that are added into specific locations by the ribosome using an altered mRNA. To date, over …

[PDF][PDF] THE EFFECTS OF INTER-TETRAMERIC LINK STRUCTURE ON COOPERATIVITY IN NOVEL, HEMOGLOBIN EIS-TETRAMIERS

D Hu - 2009 - collectionscanada.gc.ca
New reagents were designed to cross-link human deoxyhemoglobin site-selectively and
connect two hemoglobin tetramers with a semi-rigid linker that permits torsional movements …

[PDF][PDF] Type I interferons regulate immune responses in humans with blood-stage Plasmodium falciparum infection

…, FH Amante, M Sheel, RJ Faleiro, PT Bunn… - Cell reports, 2016 - cell.com
The development of immunoregulatory networks is important to prevent disease. However,
these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we …