User profiles for Simon Ducharme

Simon Ducharme

McGill University
Verified email at mcgill.ca
Cited by 4883

Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders

S Ducharme, A Dols, R Laforce, E Devenney, F Kumfor… - Brain, 2020 - academic.oup.com
The behavioural variant of frontotemporal dementia (bvFTD) is a frequent cause of early-onset
dementia. The diagnosis of bvFTD remains challenging because of the limited accuracy …

[HTML][HTML] Cigarette smoking and thinning of the brain's cortex

S Karama, S Ducharme, J Corley… - Molecular …, 2015 - nature.com
Cigarette smoking is associated with cognitive decline and dementia, but the extent of the
association between smoking and structural brain changes remains unclear. Importantly, it is …

Anxious/depressed symptoms are linked to right ventromedial prefrontal cortical thickness maturation in healthy children and young adults

S Ducharme, MD Albaugh, JJ Hudziak… - Cerebral …, 2014 - academic.oup.com
The relationship between anxious/depressed traits and neuromaturation remains largely
unstudied. Characterizing this relationship during healthy neurodevelopment is critical to …

Right anterior cingulate cortical thickness and bilateral striatal volume correlate with child behavior checklist aggressive behavior scores in healthy children

S Ducharme, JJ Hudziak, KN Botteron, H Ganjavi… - Biological …, 2011 - Elsevier
BACKGROUND: The anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), and basal
ganglia have been implicated in pathological aggression. This study aimed at identifying …

[HTML][HTML] Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial

…, EGB Vijverberg, PP De Deyn, S Ducharme… - Nature medicine, 2023 - nature.com
Tau plays a key role in Alzheimer’s disease (AD) pathophysiology, and accumulating
evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT …

Trajectories of cortical thickness maturation in normal brain development—The importance of quality control procedures

S Ducharme, MD Albaugh, TV Nguyen, JJ Hudziak… - Neuroimage, 2016 - Elsevier
Several reports have described cortical thickness (CTh) developmental trajectories, with
conflicting results. Some studies have reported inverted-U shape curves with peaks of CTh in …

Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study

…, A Gerhard, CU Onyike, S Ducharme… - The Lancet …, 2020 - thelancet.com
Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with
about a third of cases being genetic. Most of this genetic component is accounted for by …

Testosterone-related cortical maturation across childhood and adolescence

TV Nguyen, J McCracken, S Ducharme… - Cerebral …, 2013 - academic.oup.com
Neuroendocrine theories of brain development hold testosterone as the predominant factor
mediating sex-specific cortical growth and the ensuing lateralization of hemispheric function. …

Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study

…, I Santana, C Butler, S Ducharme… - The Lancet …, 2019 - thelancet.com
Background Neurofilament light chain (NfL) is a promising blood biomarker in genetic
frontotemporal dementia, with elevated concentrations in symptomatic carriers of mutations in GRN…

Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia

…, F Tagliavini, I Santana, S Ducharme… - Journal of Neurology …, 2020 - jnnp.bmj.com
Background There are few validated fluid biomarkers in frontotemporal dementia (FTD). Glial
fibrillary acidic protein (GFAP) is a measure of astrogliosis, a known pathological process …