User profiles for Simon Ducharme
Simon DucharmeMcGill University Verified email at mcgill.ca Cited by 4883 |
Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders
The behavioural variant of frontotemporal dementia (bvFTD) is a frequent cause of early-onset
dementia. The diagnosis of bvFTD remains challenging because of the limited accuracy …
dementia. The diagnosis of bvFTD remains challenging because of the limited accuracy …
[HTML][HTML] Cigarette smoking and thinning of the brain's cortex
Cigarette smoking is associated with cognitive decline and dementia, but the extent of the
association between smoking and structural brain changes remains unclear. Importantly, it is …
association between smoking and structural brain changes remains unclear. Importantly, it is …
Anxious/depressed symptoms are linked to right ventromedial prefrontal cortical thickness maturation in healthy children and young adults
S Ducharme, MD Albaugh, JJ Hudziak… - Cerebral …, 2014 - academic.oup.com
The relationship between anxious/depressed traits and neuromaturation remains largely
unstudied. Characterizing this relationship during healthy neurodevelopment is critical to …
unstudied. Characterizing this relationship during healthy neurodevelopment is critical to …
Right anterior cingulate cortical thickness and bilateral striatal volume correlate with child behavior checklist aggressive behavior scores in healthy children
BACKGROUND: The anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), and basal
ganglia have been implicated in pathological aggression. This study aimed at identifying …
ganglia have been implicated in pathological aggression. This study aimed at identifying …
[HTML][HTML] Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial
…, EGB Vijverberg, PP De Deyn, S Ducharme… - Nature medicine, 2023 - nature.com
Tau plays a key role in Alzheimer’s disease (AD) pathophysiology, and accumulating
evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT …
evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT …
Trajectories of cortical thickness maturation in normal brain development—The importance of quality control procedures
Several reports have described cortical thickness (CTh) developmental trajectories, with
conflicting results. Some studies have reported inverted-U shape curves with peaks of CTh in …
conflicting results. Some studies have reported inverted-U shape curves with peaks of CTh in …
Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study
…, A Gerhard, CU Onyike, S Ducharme… - The Lancet …, 2020 - thelancet.com
Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with
about a third of cases being genetic. Most of this genetic component is accounted for by …
about a third of cases being genetic. Most of this genetic component is accounted for by …
Testosterone-related cortical maturation across childhood and adolescence
Neuroendocrine theories of brain development hold testosterone as the predominant factor
mediating sex-specific cortical growth and the ensuing lateralization of hemispheric function. …
mediating sex-specific cortical growth and the ensuing lateralization of hemispheric function. …
Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study
…, I Santana, C Butler, S Ducharme… - The Lancet …, 2019 - thelancet.com
Background Neurofilament light chain (NfL) is a promising blood biomarker in genetic
frontotemporal dementia, with elevated concentrations in symptomatic carriers of mutations in GRN…
frontotemporal dementia, with elevated concentrations in symptomatic carriers of mutations in GRN…
Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia
…, F Tagliavini, I Santana, S Ducharme… - Journal of Neurology …, 2020 - jnnp.bmj.com
Background There are few validated fluid biomarkers in frontotemporal dementia (FTD). Glial
fibrillary acidic protein (GFAP) is a measure of astrogliosis, a known pathological process …
fibrillary acidic protein (GFAP) is a measure of astrogliosis, a known pathological process …