Infant gliomas have paradoxical clinical behavior compared to those in children and adults:
low-grade tumors have a higher mortality rate, while high-grade tumors have a better …

Infant gliomas have paradoxical clinical behavior compared to those in children and adults:
low-grade tumors have a higher mortality rate, while high-grade tumors have a better …

CNS germinomas have an excellent prognosis with radiation therapy alone. However, in
children, volume and dose of CNS radiation are associated with neurocognitive and …

Purpose The aim of this study was to determine the practice patterns and outcomes of
intracranial germ cell tumors (IGCT) in adolescents and young adults according to different …

Purpose To describe a series of children with extensive PNF or treatment refractory PLGG
treated on a compassionate basis with trametinib. Methods We report on six patients with NF‐…

Purpose The purpose of this study is to describe the long-term toxicities of intracranial germ
cell tumor (IGCT) in the adolescent and young adult (AYA) population. Methods We report …

The discovery of humans with monogenic disorders has a rich history of generating new
insights into biology. Here we report the first human identified with complete deficiency of …

Primary CNS tumors are the leading cause of cancer-related death in pediatrics. It is essential
to understand treatment trends to interpret national survival data. In Canada, children with …

In children with CNS tumours, a single sign or symptom, unless it is a prominent focal
abnormality on neurologic examination, is uncommon at the time of diagnosis. In a series from …

The purpose was to describe the incidence and risk factors associated with early deaths (≤
42 days from diagnosis) among children with acute lymphoblastic leukemia (ALL) and acute …