Importance Opioid prescribing and overdose are leading public health problems in North
America, yet the precise public health burden has not been quantified. Objective To examine …

Background This study evaluated the risk of long-term analgesic use after low-risk surgery
in older adults not previously prescribed analgesics. Methods We conducted a retrospective …

Background Opioids are widely prescribed for chronic nonmalignant pain, often at doses
exceeding those recommended in clinical practice guidelines. However, the risk-benefit ratio of …

Objective To examine the risk of new onset diabetes among patients treated with different
HMG-CoA reductase inhibitors (statins). Design Population based cohort study with time to …

Objective To describe the contributions of prescribed and non-prescribed opioids to opioid
related deaths. Design Population based cohort study. Setting Ontario, Canada, from 1 …

Background: Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …

Objective To characterise whether some selective serotonin reuptake inhibitor (SSRI)
antidepressants reduce tamoxifen’s effectiveness by inhibiting its bioactivation by cytochrome …

Background Prescription opioid use is highly associated with risk of opioid-related death,
with 1 of every 550 chronic opioid users dying within approximately 2.5 years of their first …

ContextThiazolidinediones (TZDs), used to treat type 2 diabetes, are associated with an
excess risk of congestive heart failure and possibly acute myocardial infarction. However, the …

Background Antipsychotic therapy is widely used to treat behavioral problems in older adults
with dementia. Cohort studies evaluating the safety of antipsychotic therapy generally focus …